Table 1 Effects of Pb²⁺ exposure on brain redox environment.

	23 PND
	Hippocampus		Striatum		Cortex		Cerebellum
	C	Pb²⁺	C	Pb²⁺	C	Pb²⁺	C	Pb²⁺
ROS (mg of DCF/mg of protein)	0.33 + 0.03	0.57 + 0.05*	0.85 + 0.08	1.46 + 0.08*	1.30 + 0.09	1.52 + 0.03*	0.79 + 0.06	1.20 + 0.07*
Lipid peroxidation (µmoles of MDA/mg of protein)	0.037 + 0.001	0.077 + 0.008*	0.042 + 0.004	0.069 + 0.001*	0.026 + 0.002	0.036 + 0.001*	0.021 + 0.001	0.046 + 0.004*
MTT (% vs. Control)	100 + 5.1	65.77 + 4.77*	100 + 4.2	68.75 + 4.75*	100 + 5.0	48.05 + 5.55*	100 + 8.4	60.11 + 5.61*
GSH (nmol/g of tissue)	2689.72 + 84.72	2630.15 + 89.85	2485.13 + 184.87	2531.12 + 278.88	2541.32 + 51.32	2603.96 + 88.96	2742.99 + 52.99	2548.51 + 48.51*
	60 PND
ROS (mg of DCF/mg of protein)	0.86 + 0.084	0.93 + 0.068	1.22 + 0.203	1.69 + 0.31	0.35 + 0.017	0.27 + 0.051	0.21 + 0.011	0.19 + 0.021
Lipid peroxidation (µmoles of MDA/mg of protein)	0.42 + 0.057	0.737 + 0.143*	0.464 + 0.071	0.7 + 0.1	0.26 + 0.028	0.25 + 0.055	0.110 + 0.01	0.25 + 0.07*
MTT (% vs. Control)	100 + 4.2	50.76 + 5.74*	100 + 16	46.54 + 3.46*	100 + 4.1	53.38 + 3.62*	100 + 7.2	75.76 + 5.24*
GSH (nmol/g of tissue)	2583.66 + 111.34	2573.11 + 131.89	2146.92 + 233.08	2237.48 + 137.52	2323.63 + 66.37	2246.58 + 153.42	2668.05 + 91.95	2256.63 + 83.37*

Data were obtained in different cerebral regions: hippocampus, striatum, cortex and cerebellum at 23 and 60 PND. Data are mean ± S.E.M. T-test and Mann-Whitney test were used for comparisons, *P < 0.01 vs. each respective brain region control, n = 5–8 per group.

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