Table 2 Cox model with hazard ratios and 95% confidence intervals of SARDs associated with and without leptospirosis.

From: A cohort study: The Association Between Autoimmune Disorders and Leptospirosis

Variable

SARDs

Crude*

Adjusted

no. (n = 103)

HR

(95% CI)

p-value

HR

(95% CI)

p-value

Leptospirosis

No

77

1.00

reference

 

1.00

reference

 

Yes

26

4.16

(2.67–6.50)

<0.0001

4.42

(2.82–6.92)

<0.0001

Sex

Female

61

1.00

reference

 

1.00

reference

 

Male

42

0.31

(0.21–0.46)

<0.0001

0.33

(0.22–0.48)

<0.0001

Age at baseline, years

20–39 years

13

1.00

reference

 

1.00

reference

 

40–64 years

59

2.38

(1.31–4.34)

0.0046

2.30

(1.26–4.20)

0.0068

Older than 65 years

31

2.67

(1.39–5.10)

0.0030

2.69

(1.38–5.25)

0.0036

Baseline comorbidities

Diabetes

3

0.60

(0.19–1.89)

0.3828

0.45

(0.14–1.49)

0.1914

Hypertension

8

0.89

(0.43–1.83)

0.7465

0.71

(0.31–1.65)

0.4295

Coronary artery disease

4

1.00

(0.37–2.71)

0.9956

1.01

(0.34–2.98)

0.9812

Cerebrovascular disease

4

1.05

(0.39–2.84)

0.9287

1.04

(0.35–3.06)

0.9464

  1. *Represents relative hazard ratio (HR); represents adjusted HR: mutually adjusted for leptospirosis, age, gender, and baseline comorbidities (diabetes, hypertension, coronary artery disease, and cerebrovascular disease) in Cox proportional hazard regression. Abbreviations: SARDs, systemic autoimmune rheumatic diseases; CI, confidence interval.