Figure 1 | Scientific Reports

Figure 1

From: Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction

Figure 1

Grb14 Gene Expression in Adipose Tissue Are Negatively Correlated with Metabolic Health in Human. (A) Study on metabolically healthy obese (MHO) and metabolically unhealthy obese people (MUO) (n = 15). (B) A longitudinal analysis of women with obesity before and after 20 ± 1% weight loss, induced by lifestyle therapy (low-calorie diet) or Roux-en-Y gastric bypass surgery (n = 10). (C) A longitudinal analysis of people with MUO before and after 5.9 ± 0.3% weight gain, induced by consuming an additional 1000 kcal/day until a targeted 5–7% weight gain was achieved (n = 7). *P < 0.05, Student’s t-test.

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