Figure 3 | Scientific Reports

Figure 3

From: Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction

Figure 3

Grb14 Knockdown Did Not Cause Cardiac Dysfunction. (A) Fractional shortening (FS) during a four-month HFD in C57BL/6J male mice (n ≥ 6). Shown on the right are representative images of echocardiographic measurements (M-mode) of hearts at four months. (B) Heart rate during a four-month HFD in C57BL/6J male mice (n ≥  6). (C) Heart weight normalized to brain weight after a five-month HFD in C57BL/6J male mice (n ≥  6). (D) Left ventricular internal diameter (LVID) thickness during a four-month HFD in C57BL/6J male mice (n ≥ 6). d: systolic s: diastolic. *P < 0.05, **P < 0.01 Compared to lean mice, One-way ANOVA.

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