Table 1 16 metabolic genes predicted to be selectively lethal based on tumor-specific model but missed by the pseudo-bulk model for prostate cancer tissue section 1.2.

From: Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities

Genes lethal in tumor not in bulk model

Pathways

Alternative gene not in tumor model

CPOX

Heme synthesis

FH

HMBS

Heme synthesis

ABCC1

Heme synthesis

PPOX

Heme synthesis

UGDH

Heme synthesis

UROD

Heme synthesis

UROS

Heme synthesis

SLC35D1

Heme synthesis

UGT1A8

Heme synthesis

SLC3A2

Cysteine metabolism

CBS

SLC7A11

Cysteine metabolism

AACS

Acetyl-Acetate-CoA

ACAT2

SLC6A14

Tryptophan transport

SLC16A10

SLC6A12

Glycine betaine transport

BHMT

FASN

De novo fatty acid synthesis

ADK1

SLC25A1

De novo fatty acid synthesis

  1. Column 1 lists genes specifically lethal in the tumor-specific model but not the pseudo-bulk model built with mean expression across all spatial locations. Column 2 lists the pathways of genes in column 1. Column 3 lists genes that are not present in the tumor-specific model but present in the bulk model and underlie the differential lethality of genes in column 1 (i.e., genes in column 3 provide an alternative metabolic path).
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