Table 1 Demographics Of The Study Participants.

From: Disrupted principal network organisation in multiple sclerosis relates to disability

 

HCs (n = 51)

MS patients (n = 122)

RRMS (n = 58)

PPMS (n = 28)

SPMS (n = 36)

*P values

Demographics

Age, years

41 ± 13

48 ± 11

42 ± 10

52 ± 9

53 ± 7

p < 0.001a

Gender (M/F)

25/26

36/86

18/40

10/18

8/28

p = 0.06b

Disease duration, years

—

15 ± 10

11 ± 8

14 ± 7

22 ± 10

p < 0.001a

% (no) patients of DMTs

—

58 (67)

84 (48)

13 (3)

47(16)

p < 0.001b

LL (ml)

—

14.37 ± 15.92

12.78 ± 15.72

16.56 ± 19.83

15.23 ± 12.73

p < 0.001a

Clinical scores

EDSS, median

—

5.5 (0–8.5)

2 (0–7)

6 (3–8)

6.5 (4–8.5)

p < 0.001a

SDMT

65.08 ± 8.31

45.50 ± 13.27

51.04 ± 14.28

42.86 ± 9.46

39.00 ± 10.88

p < 0.001a

  1. Abbreviations: HCs = Healthy controls; MS = multiple sclerosis; RRMS = relapsing remitting MS; PPMS = primary progressive MS; SPMS = secondary progressive MS; DMT = Disease Modifying Treatment; LL = Lesion load; EDSS = Expanded Disability Status Scale; SDMT = Symbol Digit Modalities Test; ANOVA = analysis of variance.
  2. *P values in bold denote statistical significance at p < 0.05; statistical test between the various clinical subtypes and healthy controls where applicable.
  3. aOne-way ANOVA.
  4. bChi Squared test.
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