Figure 2 | Scientific Reports

Figure 2

From: Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism

Figure 2

Partial sequence alignment of Asc-1 (blue) versus AdiC (PDB ID: 5J4I, chain A colored in beige), GkApcT (PDB ID: 5OQT, chain A colored in green), BasC (PDB ID: 6F2W colored in violet) and apo human LAT1–4F2hc (PDB ID: 6IRS, chain B colored in orange) showing conserved regions located in the TM1 and TM6 helices. The amino acid numbering scheme is based on the individual proteins. Unwound regions of TM1 and TM6 (framed in red) are very well conserved in the five sequences (more than 50% SI). The amino acids indicated in bold are involved in conserved interactions with the substrate within the binding site.

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