Figure 4 | Scientific Reports

Figure 4

From: Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism

Figure 4

Homology model of Asc-1 in the outward-open occluded conformation before and after docking d-serine. TM1 et TM6 are colored as in Fig. 3. (a) Side view of the OOO conformation. (b) Zoom on the top view of the OOO conformation after docking d-serine. Similar bindings are observed as in Fig. 3 between the backbone of TM1, TM6, TM8 and the amino acid moiety of the substrate. Specific vdw and H-bound contacts are also observed between TM6, TM8 and d-serine side chain. (c) A 2D diagram of interactions between the Asc-1 OOO model and d-serine.

Back to article page