Figure 4 | Scientific Reports

Figure 4

From: Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction

Figure 4

Application of inhibitory input to vM1 infarction can mimic temporal coding in sham animals. (A), The loss of excitatory inputs to vS1 L5b (dotted area) was visualised by CSD analysis at POD3. (B), Upper, An example of the recorded vS1 L2/3 responses at POD3. Lower, Simulated inhibition from vM1 (cyan line) suppressed the sustained responses. (C), TCI was recovered to the sham level in simulated vS1 responses: in L2/3, TCI at POD3 of recorded (0.85 ± 0.03) and simulated (1.00 ± 0.03); in L5b, TCI at POD3 of recorded (0.87 ± 0.03) and simulated (1.06 ± 0.01); in L5b, TCI at POD14 of recorded (0.94 ± 0.03) and simulated (1.05 ± 0.01). Each value was normalised to the level of sham mice. *P < 0.05; **P < 0.01; Dunnett’s test was used to compare with the sham level. ns, not significant. To calculate normalised TCI, the response to the first stimulus (from the stimulus onset until 180 ms) was used.

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