Figure 3
From: Chemokine releasing particle implants for trapping circulating prostate cancer cells
Slow release property and cell/tissue compatibility of HA particles. The slow release property, cell and tissue compatibility of hyaluronic acid (HA) particles with crosslinking densities (DVS: HA = 6.33:1, labeled as “HA”) were characterized. (A) The release rate of Cy5 labeled EPO or SDF-1α (Cy5-EPO or Cy5-SDF-1α) was quantified in vitro. (B) The cell compatibility of HA particles was determined using 3T3 fibroblasts in vitro (n = 5). (C) The tissue compatibility of HA particles was measured in vivo using subcutaneous implantation mice model. The density of inflammatory cells surrounding particle implants was quantified histologically to reflect the extent of tissue compatibility of different particle implants (100x magnification). (n = 3) Data are mean ± SD. (Student’s t-test, *indicates p < 0.05 versus Saline group).
