Table 1 Functional enrichment analysis of DEGs in IVD cells using GSEA.
Gene Set Name | SIZE | ES | NES | P-value |
|---|---|---|---|---|
Upregulated | ||||
REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION | 25 | 0.647 | 2.294 | 0.000 |
ATP_GENERATION_FROM_ADP | 35 | 0.571 | 2.175 | 0.000 |
RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN | 134 | 0.425 | 2.127 | 0.000 |
RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS | 54 | 0.495 | 2.121 | 0.000 |
ADP_METABOLIC_PROCESS | 41 | 0.519 | 2.098 | 0.000 |
GLUCOSE_CATABOLIC_PROCESS | 28 | 0.574 | 2.060 | 0.000 |
Downregulated | ||||
LYSOSOME_LOCALIZATION | 18 | 0.676 | 1.855 | 0.000 |
MAST_CELL_MEDIATED_IMMUNITY | 16 | 0.693 | 1.842 | 0.004 |
MAST_CELL_ACTIVATION | 19 | 0.662 | 1.810 | 0.003 |
NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS | 17 | 0.677 | 1.802 | 0.001 |
RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC | 41 | 0.559 | 1.782 | 0.001 |
NEUROPEPTIDE_RECEPTOR_ACTIVITY | 30 | 0.584 | 1.773 | 0.000 |
