Table 3 Summaries for the function of 4 significant genes.

From: Identification of significant gene biomarkers of low back pain caused by changes in the osmotic pressure of nucleus pulposus cells

No.

Gene symbol

Full name

Function

1

CCL5

C-C Motif Chemokine Ligand 5

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils.

2

OPRL1

Opioid Related Nociceptin Receptor 1

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin.

3

SST

Somatostatin

Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

4

CXCL13

C-X-C Motif Chemokine Ligand 13

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes.

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