Table 6 Diagnostic performance of interpretative criteria for prediction of complete response and progressive disease for indeterminate scores applied to all primary tumours, all nodal disease, HPV-positive OPC, HPV-negative OPC and hypopharynx/larynx sub-groups. () = number of indeterminate cases.
NI-RADS (n = 91) | Porceddu (n = 25) | Hopkins (n = 13) | Deauville (n = 20) | Mean | |
|---|---|---|---|---|---|
All Primary Tumour | |||||
Sensitivity | 41 | 11.67 | 9.23 | 9.84 | 17.9 |
Specificity | 85 | 94.46 | 97.89 | 95.71 | 93.3 |
PPV | 41.76 | 28 | 46.15 | 30 | 36.5 |
NPV | 85.08 | 85.28 | 84.6 | 85.01 | 85.0 |
Accuracy | 76.38 | 81.56 | 83.3 | 82.17 | 80.9 |
All Node | |||||
NI-RADS (n = 55) | Porceddu (n = 70) | Hopkins (n = 3) | Deauville (n = 18) | Mean | |
Sensitivity | 39.02 | 32.81 | 4.62 | 15.62 | 23.0 |
Specificity | 93.11 | 85.02 | 100 | 97.55 | 91.9 |
PPV | 58.18 | 30 | 100 | 55.56 | 47.9 |
NPV | 86.15 | 86.6 | 84.06 | 85.52 | 85.6 |
Accuracy | 82.45 | 76.47 | 84.18 | 84.14 | 81.8 |
All HPV-positive OPC | |||||
NI-RADS (n = 32) | Porceddu (n = 9) | Hopkins (n = 4) | Deauville (n = 8) | Mean | |
Sensitivity | 42.31 | 56.52 | 4.35 | 21.74 | 31.2 |
Specificity | 96.86 | 88.46 | 100 | 99.36 | 94.9 |
PPV | 68.75 | 41.94 | 100 | 83.33 | 64.7 |
NPV | 91.12 | 93.24 | 87.64 | 89.6 | 90.4 |
Accuracy | 89.19 | 84.36 | 87.71 | 89.39 | 87.7 |
All HPV-negative OPC | |||||
NI-RADS (n = 9) | Porceddu (n = 2) | Hopkins (n = 1) | Deauville (n = 1) | Mean | |
Sensitivity | 50 | 28.57 | 12.5 | 14.29 | 26.3 |
Specificity | 85.71 | 100 | 100 | 100 | 85.7 |
PPV | 55.56 | 100 | 100 | 100 | 55.6 |
NPV | 82.76 | 82.76 | 77.42 | 80 | 80.7 |
Accuracy | 76.32 | 83.87 | 78.12 | 80.65 | 79.7 |
All Hypopharynx/Larynx | |||||
NI-RADS (n = 23) | Porceddu (n = 2) | Hopkins (n = 3) | Deauville (n = 2) | Mean | |
Sensitivity | 34.48 | 5 | 0 | 5 | 14.8 |
Specificity | 77.59 | 97.83 | 93.88 | 97.83 | 91.8 |
PPV | 43.48 | 50 | 0 | 50 | 47.8 |
NPV | 70.31 | 70.31 | 69.7 | 70.31 | 70.2 |
Accuracy | 63.22 | 69.7 | 66.67 | 69.7 | 67.3 |
