Table 1 Pharmacokinetic parameters of acetaminophen from a single oral administration of 100 mg/kg 14C-acetaminophen following exposure to antibiotics in C57Bl/6 mice.
From: Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice
Treatment | Cmax (µg/mL) | Tmax (hr) | T1/2 (hr) | AUC (µg•hr/mL) |
|---|---|---|---|---|
control | 105.6 | 0.25 | 0.46 | 55.3 |
ciprofloxacin | 98.6 | 0.25 | 0.48 | 49.9 |
amoxicillin | 80.9* | 0.25 | 0.48 | 45.8 |
ampicillin/neomycin | 62.8* | 0.25 | 0.66 | 43.9 |
