Table 2 Acetaminophen metabolites recovered in mouse urine after a single oral administration of 100 mg/kg 14C-acetaminophen following exposure to antibiotics in C57Bl/6 mice.

From: Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice

Treatment group

Sulfate

Glucuronide

Sulfate/Glucuronide

Control

10.84 ± 2.85

78.87 ± 2.99

0.14

Ciprofloxacin

15.11 ± 2.51

67.52 ± 5.19*

0.22*

Amoxicillin

7.49 ± 1.34

79.91 ± 1.39

0.09

Ampicillin/neomycin

2.71 ± 0.26*

87.54 ± 1.27*

0.03*

  1. Data is expressed as the mean percent recovered radioactivity (n = 4 ± SD).
  2. *Significantly different from controls. (p < 0.05).
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