Table 2 Key driver genes.

GSTM3

Plays a role in cell protection against oxidative damages; involved in tumor progression^37,52

x

x

x

x

GSTA1

Takes part in detoxification process; associated with tumor progression^69,70,71

x

GSTM1

Important role in Phase II detoxification process^37,72

x

x

x

TFF3

Maintains the integrity of the gastrointestinal tract; promote proliferation, invasion and EMT^73,74,75

x

x

ITGA2

Regulates cytoskeletal organization and cellular motility; implicated in stem cell differentiation^76,77

x

x

x

ERBB3

Linked to cancer etiology and progression; its role in EMT is still under debate^78,79

x

x

x

LPIN1

Involved in phospholipid and triacylglycerol synthesis; catalyzes the dephosphorylation of phosphatidate to diacylglycerol (DAG)^80,81

x

LPIN2

Plays central role in lipid metabolism; catalyzes the dephosphorylation of phosphatidate to diacylglycerol (DAG)^80,81

x

LPIN3

Has a role in lipid metabolism; expressed in the gastrointestinal tract and liver^38,80,81

x

x

PLPP2

Involved in lysophosphatidic acid degradation^38,41

x

x

KCNE3

Modulates the voltage-gated potassium (Kv) channels gating^56,82

x

x

KLHL14

Participates in extracellular communication/interaction, cell morphology and actin binding regulation⁴³

x

x