Figure 2
From: Longitudinal phenotype development in a minipig model of neurofibromatosis type 1
Subject with neurofibroma progression visualized with computed tomography (CT) (shown in coronal whole-body view) at (A) 4-months and (B) 12-months using the low-dose CT (LDCT) protocol and (C) 12-months using the standard-dose CT protocol. Note the granularity differences between CT and LDCT at time point 3 (TP3: 12 months of age), particularly in the areas (S1-S3) that were biopsied for histopathology. Comparison to litter-mate male wildtype with same scanning history (D) Demonstrates the ‘typical’ CT presentation of the lean body mass and hardening of uncastrated male pigs’ skin. Comparison to littermate female wildtype with same scanning history (E) shows the increased fat content in the intact female compared to intact boar. Window/level set to abdominal view.
