Table 2 Selected SNPs within NFKB-related genes.

GBP6

1

rs928655

A/G

A

Intronic

Associated with etanercept response in moderate-to-severe plaque psoriasis⁴⁷

IKBKB

8

rs11986055

A/C

A

Intronic

IRF4

6

rs1050975

A/G

A

3′-UTR/ncRNA

IRF4

6

rs12203592

C/T

T

Intronic

Correlated with white blood cell count⁴⁸

IRF4

6

rs1877175

C/T

T

3′-UTR/ncRNA

IRF4

6

rs7768807

T/C

T

3′-UTR/ncRNA

KLRC1

12

rs7301582

C/T

T

Intronic

Associated with response to anti-TNF therapy in RA patients⁴⁹

KLRK1 | KLRC4

12

rs1049174

C/G

C

3′UTR/Intronic

Associated with response to anti-TNF therapy in RA patients⁵⁰

KLRK1 | KLRC4

12

rs1154831

A/C

A

Intronic/Near gene

Lack of association with response to anti-TNF therapy⁵⁰

KLRK1 | KLRC4

12

rs2255336

A/G

A

Thre72Ala

Correlation with blood NKG2D type II integral membrane protein levels⁵¹ and associated with response to anti-TNF therapy in RA patients⁵⁰; Associated with a decreased risk of Lupus erythematosus^52,53

LOC105376246

9

rs2722824

A/C

A

Near gene

NFKB1

4

rs4648110

A/T

A

Intronic

NFKB2

10

rs11574851

C/T

T

Asn698Asn

NFKB2

10

rs12769316

C/T

T

Near gene

NFKB2 | PSD

10

rs1056890

C/T

T

Near gene/3′-UTR

NFKBIB

19

rs3136645

C/T

C

ncRNA

Associated with response to anti-TNF drugs in RA patients²⁵

NLRP3

1

rs4612666

C/T

T

Intronic

Associated with response to anti-TNF drugs in RA patients⁴²

REL

2

rs13031237

G/T

T

Intronic

Overall association with the risk of RA at GWAS level^29,54,55. Association with RA in ACPA-positive individuals at GWAS level⁵⁵; Association with early-onset psoriasis⁵⁶ and autoimmune diseases⁵⁷ in large candidate gene association studies

REL

2

rs842647

A/G

A

Intronic

Associated with susceptibility to Behcet’s disease⁵⁸

REL

2

rs13017599

A/G

A

Near gene

Associated with RA and psoriatic arthritis at GWAS level^29,59 and in a candidate gene association study⁶⁰

RELA

11

rs11820062

C/T

T

Intronic

Eosinophil counts⁴⁸

RELA

11

rs2306365

A/G

A

Intronic

RELA

11

rs7119750

C/T

T

Intronic

TLR10

4

rs11096957

A/C

A

Asn241His

Associated with hip osteoarthritis^61,62 and effectiveness of biologics for psoriasis treatment at GWAS level⁶³

TLR4

9

rs4986791

C/T

T

Thr399Ile

TLR4: lymphocyte 96 antigen complex level⁵¹; Associated with RA risk and response to anti-TNF drugs⁶⁴; Associated with risk of developing inflammatory bowel disease⁶⁵

TLR5

1

rs5744174

C/T

C

Phe616Leu

Associated with response to anti-TNF drugs in RA patients²⁷; Associated with the risk of Crohns disease⁶⁶ and response to anti-TNF treatment⁶⁷; Associated with response to ustekinumab treatment in psoriasis patients⁶⁸

TLR9 | | TWF2

3

rs187084

G/A

T

Near gene

Associated with psoriatic arthritis risk⁶⁹, hip and knee osteoarthritis^70,71, SLE⁷² and IBD⁷³; associated with the risk of autoimmune thyroid disease⁷⁴; response to anti-TNF therapy in patients with RA⁶⁴ and IBD⁷⁵

TRAF1 | | C5

9

rs3761847

A/G

A

Near gene

Associated with RA at GWAS level^54,76