Table 5 Overall and ACPA-stratified haplotype association analysis for RA.
NFKB2 | rs11574851 | rs12769316 | 99999 | Freq | RA patients (n = 4210) OR (95% CI) | P | Freq | ACPA-positive patients (n = 3117) OR (95% CI) | P | Freq | ACPA-negative patients (n = 2688) OR (95% CI) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | C | C | 0.8181 | 1.00 | — | 0.8224 | 1.00 | — | 0.8295 | 1.00 | — | |
2 | C | T | 0.1139 | 1.14 (0.99–1.31) | 0.066 | 0.1706 | 1.10 (0.92–1.32) | 0.30 | 0.1088 | 1.02 (0.79–1.30) | 0.91 | |
3 | T | T | 0.0571 | 1.18 (0.98–1.42) | 0.13 | 0.0530 | 1.39 (1.11–1.74) | 0.0042 | 0.0538 | 1.04 (0.75–1.44) | 0.82 | |
4 | T | C | 0.0109 | 2.21 (1.37–3.56) | 0.0011 | — | — | — | — | — | — |
