Table 4 Multivariate logistic regression for the predictors of macular edema in patients with RVO.

model summary	Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	Sleep-trough MBPS + Average 24-hour SBP + Covariates^‡		Sleep-trough MBPS + Average daytime SBP + Covariates^‡		Sleep-trough MBPS + Average nighttime SBP + Covariates^‡		Prewaking MBPS + Average 24-hour SBP + Covariates^‡		Prewaking MBPS + Average daytime SBP + Covariates^‡		Prewaking MBPS + Average nighttime SBP + Covariates^‡
	C-index 0.745; AIC 88.58		C-index 0.681; AIC 92.40		C-index 0.681; AIC 92.40		C-index 0.746; AIC 89.14		C-index 0.729; AIC 90.56		C-index 0.719; AIC 92.20
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Binary sleep-trough MBPS*	4.74 (1.35–16.6)	0.015	4.71 (1.34–16.4)	0.015	4.77 (1.37–16.6)	0.014	—	—	—	—	—	—
Binary prewaking MBPS^†	—	—	—	—	—	—	7.12 (1.65–30.7)	0.009	5.88 (1.40–24.7)	0.015	6.93 (1.59–30.2)	0.010
Average 24-hour SBP	1.43 (0.96–2.14)	0.076	—	—	—	—	1.62 (1.06–2.46)	0.025	—	—	—	—
Average daytime SBP	—	—	—	—	—	—	—	—	1.46 (1.00–2.15)	0.052	—	—
Average nighttime SBP	—	—	—	—	—	—	—	—	—	—	1.45 (0.97–2.16)	0.071

Abbreviations: AIC, Akaike Information Criterion; CI, confidence interval; MBPS, morning blood pressure surge; OR, odds ratio; RVO, retinal vein occlusion; SBP, systolic blood pressure.
The multivariate Cox-proportional hazard model was reduced using a backward variable selection method (cut-off criteria p > 0.10).
*Cut-off point ≥29.3 mmHg; ^†Cut-off point ≥14.4 mmHg.
^‡Covariates included male, diabetes, hypertension, current smoking, dyslipidemia, LDL levels, BMI, Average PWV and Carotide IMT; None of the covariates were significantly associated with the occurrence of macular edema in all models after the variable selection process.

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