Table 3 Biological function annotation.
Variant | Promoter | Enhancer | DNAse | Proteins | Motifs | GENCODE | dbSNP | Regulome | eQTL |
|---|---|---|---|---|---|---|---|---|---|
histone marks | histone marks | Bound | Changed | Genes | func annot | DB scorea | p –valueb | ||
rs17817964 | 5 tissues | GATA3 | 5 altered motifs | FTO | intronic | 2b | — | ||
rs7185735 | 6 tissues | Gcm1,Mef2 | FTO | intronic | — | — | |||
rs9936385 | 8 tissues | 17 tissues | HDAC2,Pax-5 | FTO | intronic | 5 | — | ||
rs12149832 | BRN | 11 tissues | BRST | XBP-1 | FTO | intronic | 6 | 4 × 10−5 | |
rs9939609 | BRST | Nanog,Pou5f1 | FTO | intronic | — | — | |||
rs11075989 | BRST, FAT, LNG | 6 altered motifs | FTO | intronic | 6 | — | |||
rs11075990 | BRST, FAT, LNG | Nkx6-1,Pou4f3,Pou6f1 | FTO | intronic | 6 | — | |||
rs3751812 | 12 tissues | 7 tissues | Mrg,TBX5,Tgif1 | FTO | intronic | 3a | — | ||
rs8050136 | 8 tissues | BRST,CRVX,BRST | P300 | 6 altered motifs | FTO | intronic | 4 | — | |
rs9935401 | BRST, SKIN | Cdx,HES1 | FTO | intronic | — | — | |||
rs8051591 | BRST, CRVX, SKIN | BRST | 6 altered motifs | FTO | intronic | 6 | — | ||
rs17817449 | 11 tissues | 5 tissues | 4 altered motifs | FTO | intronic | 5 | 4 × 10−5 | ||
rs8043757 | 11 tissues | BRST,SKIN | Evi-1 | FTO | intronic | 5 | — | ||
rs9923233 | 8 tissues | 14 tissues | 8 altered motifs | FTO | intronic | 5 | — | ||
rs17817288 | MUS, LIV | 17 tissues | 6 tissues | FOXA1,FOXA2,TCF4 | 8 altered motifs | FTO | intronic | 5 | — |
rs1558902 | LNG | 16 tissues | GI | GATA | FTO | intronic | — | 5 × 10−5 | |
rs7202116 | 6 tissues | BLD | MAFF,MAFK | 7 altered motifs | FTO | intronic | 2b | — | |
rs1421085 | LIV | 14 tissues | LIV,VAS | Arid3a,HNF6 | FTO | intronic | 5 | 3 × 10−5 | |
rs9930506 | Irx | FTO | intronic | 6 | 5 × 10−5 | ||||
rs9922619 | 6 altered motifs | FTO | intronic | 6 | — | ||||
rs9922708 | HRT | HRT | HEN1,Pbx-1,TAL1 | FTO | intronic | 6 | 4 × 10−5 | ||
rs9932754 | 6 altered motifs | FTO | intronic | 6 | 5 × 10−5 | ||||
rs9930501 | Nanog,SRF | FTO | intronic | — | 4 × 10−5 | ||||
rs9931494 | FAT | 11 altered motifs | FTO | intronic | 6 | — | |||
rs7201850 | 7 tissues | Foxo,RORalpha1 | FTO | intronic | — | 1 × 10−5 | |||
rs9941349 | BRN | FTO | intronic | — | — | ||||
rs8044769 | 8 tissues | 6 tissues | JUND,CJUN | 4 altered motifs | FTO | intronic | 4 | 1 × 10−5 | |
rs9922047 | FAT | 13 tissues | FTO | intronic | 5 | — | |||
rs11075987 | LNG | 14 tissues | 8 tissues | STAT3 | intronic | 4 | 5 × 10−5 |
