Figure 2
From: Phenome-Wide Scan Finds Potential Orofacial Risk Markers for Cancer
Plot representing the phenome-wide association analysis in the cancer-affected sample. The horizontal red line indicates the threshold of p = 0.002; the horizontal blue line indicates the threshold of p = 0.05, phenotypes found below the blue line (p > 0.05 – not associated) are not annotated in the plots to avoid noise. The triangle tip direction represents the odds ratio direction of each association, upward triangles indicate OR ≥ 1; downward triangles indicate a protective effect (OR < 1.0); different triangle colors indicate different disease groups (from left to right – light red=circulatory system, green=digestive, dark red=dermatologic and light blue=congenital anomalies). (a) AXIN2 - rs11867417 and its association with loss of teeth/edentulism, and its protective effect towards gingivitis (p < 0.05). (b) AXIN2 - rs2240308 and its association with loss of teeth/edentulism and its protective effect against leukoplakia of the oral mucosa (p < 0.05). (c) RHEB - rs1109089 and its protective effect against periodontitis (p < 0.05).
