Figure 1 | Scientific Reports

Figure 1

From: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

Figure 1

No loss or surplus of cerebellar lobes was observed in granule cells from Jdp2-KO mice, where lower expression of Atoh-1 was detected in these cells. (a) β-Gal staining at P6 in Jdp2-Cre/ROS26R mice showed signals in the regions rich in cerebellar granule cells (magnification 20×) (GCPs; right panel; magnification 100×). (b) Haematoxylin and eosin staining of the cerebellum from WT 129-C57/BL6J and Jdp2-KO 129-C57/BL6J mice. (c) GCPs were prepared from WT and Jdp2-KO mice and stained for Atoh-1. Atoh-1-stained cells were quantified according to the calculation presented in Materials and Methods. *p < 0.05. (d) Western blot analysis showed that the expression of Atoh-1 was about 87% lower in GCPs from Jdp2-KO mice than in those from WT mice.

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