Figure 5
From: Insulin activates hepatic Wnt/β-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine
Model for the molecular mechanism involving insulin-induced hepatic Wnt signaling activity through SCD1, palmitoleate and Porcupine. Insulin stimulates de novo lipogenesis through PI3K/mTORC1 signaling, leading to the expression of the fatty acid desaturase SCD1. This lipogenic enzyme acts as a supplier of palmitoleate used as a substrate by the acyltransferase Porcupine to activate the Wnt signaling pathway. Thus, during refeeding, insulin is an upstream regulator of SCD1, which in concert with Porcupine may stimulate hepatic Wnt/β-catenin activity.
