Figure 2

(A–C) Plot of the product of the best fit Hill slopes and calculated Bliss, CI, and BRAID κ for each combination of drugs in each cell line from the OPSS. The product of the best-fit individual dose response Hill slopes is plotted on a logarithmic scale; the blue line represents the best linear fit to the data. For CI, the Y-axis has been inverted so that values representing synergy are higher, to maintain visual consistency with figures (A,C). (D) Magnitude of correlation between Hill slope product and all three interaction metrics when drugs from each of the four largest mechanistic classes are removed from the data. No class significantly reduces correlation for Bliss or CI, but two reduce the correlation for κ. (E) Effect on correlation magnitude of removing PI3K/AKT/mTOR pathway inhibitors, Other Kinase inhibitors, or both from the data. Correlations for κ are reduced, correlations for Bliss and CI are increased.