Figure 2 | Scientific Reports

Figure 2

From: Retinal Organoids derived from hiPSCs of an AIPL1-LCA Patient Maintain Cytoarchitecture despite Reduced levels of Mutant AIPL1

Figure 2

Heatmaps illustrate gene expression profiles of retinal progenitor cells (RPC), retinal transcription factors (TF), and retinal cell type-specific genes at distinct organoid stages from RNA-seq data at day (D) 25, 60, 88, and 123 (corresponding to weeks 4, 9, 13, and 18, respectively) of differentiation. RNA-Seq data show that most genes exhibited comparable expression pattern between control and AIPL1-LCA ROs at respective stages. Different colors represent the expression value as log2 transformed CPM values. Expression of each gene is represented as their average across samples N = 3–5 differentiation experiments with n = 15–20 ROs each. Blue to red represents low to high gene expression.

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