Figure 5 | Scientific Reports

Figure 5

From: Temperature but not leptin prevents semi-starvation induced hyperactivity in rats: implications for anorexia nervosa treatment

Figure 5

Daily running activity and body temperature for light (left panels) and dark periods (right panels) during food restriction (RF) phase. Top panels (A,B) are for rats of Study 1 with a preceding ad libitum baseline of 28 days. Bottom panels (C,D) represent data for rats of Study 2 with a preceding ad libitum baseline of 14 days. Rats were treated with leptin (LEP, white symbols ○, □) or vehicle (VH, dark symbols ●, ▲, ■), via implanted minipumps. Body temperature from animals which ambient temperature (Ta) during RF was maintained at 21 °C (solid lines) or 25 °C (dot dash lines), as in AL phase, or increased to 32 °C (dotted line). *p < 0.05 for 21VH vs 21LEP. #p < 0.05 and ##p < 0.01 for 21LEP vs 25LEP. Activity and body temperature are presented as mean ± SEM. Legends. Wheel running bars: 21VH, black bars; 21LEP, white bars; 32VH, dotted bars; 25VH, hatched bars; 25LEP, cross-hatched bars.

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