Figure 4 | Scientific Reports

Figure 4

From: Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Figure 4

Gnetin C mediates transient stabilisation of H2AX and a reduction in the number of γH2AX foci. (a) Dose-dependent effects of gnetin C, gnemonoside A and gnemonoside D, and time-dependent effects of gnetin C on H2AX expression in senescent MEFs (passage 8). The dose-dependent effects were assessed 3 hr after treatment. The time-dependent effect was determined using 2.5 μM gnetin C. (b) The effects of gnetin C (2.5 μM), gnemonoside A (2.5 μM) and gnemonoside D (2.5 μM) on the numbers of γH2AX foci in senescent MEFs at 3 and 24 hr post-treatment. Data in the graphs are represented as the mean ± s.d. Scale bars, 10 μm. P-values were calculated by two-tailed Welch’s t-tests.

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