Figure 5 | Scientific Reports

Figure 5

From: Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Figure 5

Melinjo resveratrol consumption contributes to the suppression of cancer associated with microsatellite instability. (a) Kaplan-Meier curves showing the survival rates of Msh2−/− mice fed a normal diet or a diet supplemented with melinjo resveratrol (0.3% or 0.03%). Data were analysed by a Log-Rank test followed by a Holm-Sidak test; n = 10 (control group), n = 13 (0.03% melinjo resveratrol group), n = 12 (0.3% melinjo resveratrol group). (b) The numbers of tumours in the small intestines of K2BrPO3-treated mice fed a normal diet or a diet supplemented with 0.03% melinjo resveratrol. Statistical analysis was performed via a Student’s t-test. (c) The MSI statuses at three microsatellite loci in tissue from normal organs (top row) and polyps (bottom row). Red arrows indicate the shifted fragment peaks, i.e., MSI.

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