Table 1 Comparisons of patient characteristics.

From: The risk of twin pregnancies should be minimized in patients with a unicornuate uterus undergoing IVF-ET

Characteristics

Unicornuate uterus

Normal uterus

Univariate analysis

Singleton (n = 139) A

SR of twins to a singleton (n = 21) B

Twins (n = 46) C

SR of twins to a singleton (n = 82) D

Twins (n = 232) E

P (A vs. B)

P (A vs. C)

P (B vs. C)

P (D vs. B)

P (E vs. C)

Maternal age (years)

29.5 ± 4.4

28.1 ± 2.9

29.2 ± 3.7

31.9 ± 3.7

29.7 ± 3.7

     

≤24

11(7.9)

2(9.5)

5(10.9)

4(4.9)

15(6.5)

0.255

0.209

0.614

0.002

0.680

25–29

69(49.6)

12(57.1)

19(41.3)

17(20.7)

97(41.8)

     

30–34

39(28.1)

7(33.3)

19(41.3)

40(48.8)

91(41.8)

     

≥35

20(14.4)

0

3(6.5)

21(25.6)

23(9.9)

     

BMI (kg/m2)

21.6 ± 3.8

21.4 ± 2.5

21.2 ± 2.9

21.2 ± 2.8

21.2 ± 2.6

     

<18.5

24(17.5)

3(14.3)

6(13.0)

12(14.6)

34(14.7)

1.000

0.276

0.693

0.882

0.874

18.5–23.9

87(63.5)

14(66.7)

35(76.1)

58(70.7)

168(72.4)

     

≥24

26(19.0)

4(19.0)

5(10.9)

12(14.6)

30(12.9)

     

FSH (mIU/mL)

6.1 ± 3.5

5.5 ± 3.2

6.1 ± 1.3

4.9 ± 3.1

5.8 ± 1.7

     

≤1.36

8(5.8)

3(14.3)

0

20(24.4)

0

0.209

0.283

0.014

0.606

0.517

1.37–9.9

127(91.4)

17(81.0)

45(97.8)

59(72.0)

229(98.7)

     

≥10.0

4(2.9)

1(4.8)

1(2.2)

3(3.7)

3(1.3)

     

Infertility duration (years)

4.8 ± 3.3

3.6 ± 2.1

5.0 ± 3.3

4.79 ± 3.12

5.7 ± 3.3

     

≤3

60(43.2)

11(52.4)

18(39.1)

35(42.7)

66(28.4)

0.235

0.819

0.175

0.246

0.271

4–6

43(30.9)

8(38.1)

14(30.4)

25(30.5)

96(41.4)

     

≥7

36(25.9)

2(9.5)

14(30.4)

22(26.8)

70(30.2)

     

Previous miscarriage

No

119(85.6)

19(90.5)

35(76.1)

73(89.0)

207(89.2)

0.741

0.134

0.203

0.848

0.015

Yes

20(14.4)

2(9.5)

11(23.9)

9(11.0)

25(10.8)

     

Transfer cycle

1.1 ± 0.4

1.1 ± 0.3

1.2 ± 0.5

1.23 ± 0.61

1.2 ± 0.4

     

1

121(87.1)

19(90.5)

41(89.1)

68(84.0)

200(86.2)

1.000

0.711

1.000

0.452

0.594

≥2

18(12.9)

2(9.5)

5(10.9)

13(16.0)

32(13.8)

     

Number of retrieved oocytes

8.8 ± 6.3

10.6 ± 5.5

11.3 ± 5.9

10.2 ± 6.6

9.7 ± 6.8

     

≤10

66(47.5)

9(42.9)

16(34.8)

30(36.6)

103(44.4)

0.692

0.133

0.526

0.597

0.229

>10

73(52.5)

12(57.1)

30(65.2)

52(63.4)

129(55.6)

     

EM thickness on transfer day (mm)

12.5 ± 2.2

12.9 ± 2.2

12.2 ± 2.1

12.5 ± 2.2

12.7 ± 2.2

     

≤7.9

1(0.7)

0

0

0

1(0.4)

1.000

0.851

0.698

0.860

0.609

8–14.9

120(86.3)

18(85.7)

41(89.1)

69(84.1)

194(83.6)

     

≥15

18(12.9)

3(14.3)

5(10.9)

13(15.9)

37(16.0)

     

Number of transferred embryos

 1

23(16.5)

0

0

0

0

0.066

0.003

1.000

1.000

1.00

 2

110(79.1)

21(100.0)

44(95.7)

79(96.3)

221(95.3)

     

 3

6(4.3)

0

2(4.3)

3(3.7)

11(4.7)

     

Infertility type

Primary

72(51.8)

16(76.2)

19(41.3)

33(40.2)

126(54.3)

0.036

0.217

0.008

0.003

0.107

Secondary

67(48.2)

5(23.8)

27(58.7)

49(59.8)

106(45.7)

     

Cause of infertility

Male factor

7(5.0)

0

1(2.2)

3(3.7)

13(5.6)

0.613

0.856

0.810

0.526

0.400

Female factor

83(59.7)

11(52.4)

27(58.7)

48(58.5)

112(48.3)

     

Combined female and male factors

47(33.8)

10(47.6)

17(37.0)

31(37.8)

105(45.3)

     

Unexplained

2(1.4)

0

1(2.2)

0

2(0.9)

     

14-day hCG (mIU/ml)

516.1 ± 261.6

1069.6 ± 264.4

1067.0 ± 404.3

967.7 ± 338.6

1015.5 ± 438.6

     

<420

59(42.4)

0

1(2.2)

2 (2.4)

14(6.0)

<0.001

<0.001

1.000

0.202

0.462

≥420

80(57.6)

21(100.0)

45(97.8)

80(97.6)

218(94.0)

     

Insemination method

IVF

72(51.8)

16(76.2)

36(78.3)

47(57.3)

190(81.9)

0.136

0.007

1.000

0.280

<0.001

ICSI

26(18.7)

2(9.5)

4(8.7)

16(19.5)

42(18.1)

     

IVF/ICSI

41(29.5)

3(14.3)

6(13.0)

19(23.2)

0(0.0)

     
  1. Abbreviations: SR, selective reduction; BMI, body mass index; FSH, follicle-stimulating hormone; EM, endometrium; hCG, human chorionic gonadotropin; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection.
  2. a. Values are given as numbers (percentages) or mean ± SD, unless otherwise indicated.