Figure 5 | Scientific Reports

Figure 5

From: Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions

Figure 5

Avocado polyol SEDDS selectively reduce viability of AML cells with enhanced potency compared to DMSO delivery. In vitro activity of avocado polyol SEDDS was evaluated in AML cell lines OCI-AML-2 and TEX. Cells were incubated with varying concentrations of avocado polyols dissolved in DMSO or as SEDDS. After 72 hours, cell viability was measured by the MTS assay. For avocadyne (A), avocadene (B), avocatin B (C), and 3:1 avocadene-avocadyne (D), 20 mg/mL (2% w/w) SEDDS were freshly prepared and used for serial dilution. For 3:2 avocadene-avocadyne (E), 15 mg/mL (1.5% w/w) SEDDS were freshly prepared and used. Data represent logarithmic transformation of avocado polyol concentrations (µg/mL) and cell viability data that was fit to a nonlinear four-parameter logistic curve to determine inhibitory concentration 50 (IC50). All data represents mean ± SEM from three independent experiments performed in triplicate.

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