Table 7 Mutations from external blind dataset predicted to be resistance causing by our models.

From: Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis

Gene

Mutations

rpoB

F430S, G432D, G432S, S434R, Q435K, L436R, S437R, Q438K, Q438R, D441E, D441N, N444K, L449S, H451D, H451N, H451Q, H451R, H451S, H451T, P460S, I486T

InhA

I16T, I21T, I47T, I95T, I194T

katG

L48Q, A61T, A65T, A66P, I71N, M84I, Q88R, G99E, A106V, W107R, H108D, H108E, H108Q, A109V, A110V, G121V, M126I, A139P, L148R, Y155S, A162T, G169A, A172T, A172V, M176I, G186V, W191R, G234E, G234R, A243S, M257T, M257I, T262R, A264T, G279D, A281V, G285D, A291P, G297V, G299A, W300G, Y304S, G305A, G307R, G307A, G307E, G309S, G309D, G316S, G316D, W321R, W321L, W321S, W328G, W328L, W328S, I335T, L336R, W341S, A350T, A350S, A361D, A379V, L384R, I393N, A409R, A409D, A424E, A424V, P429S, A444T, I462T, G485V, W505S, W505R, A550D, F567S, A574E, A574V, P589T, G593D, M609I, G629S, A636E, G685R, G699Q, A713P, A716P, A727D

pncA

A146T, A171E, A171T, G162D, L159R, L182S, S179R, T142K, T153N, T168N

gyrA

A74S, G88A

gyrB

G509A, N538K, A543T, A543V

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