Table 3 The dynamics of parameter changes during the treatment.
Parameter | Mean value 2nd day of treatment | Mean value 3rd day of treatment | Mean value 4th day of treatment | ||||||
|---|---|---|---|---|---|---|---|---|---|
Placebo group (n = 24) | Treatment group (n = 120) | P value | Placebo group (n = 24) | Treatment group (n = 120) | P value | Placebo group (n = 24) | Treatment group (n = 120) | P value | |
Weight, Me (IQR), kg | 71.0 (65.5–84.8) | 73.0 (67.0–80.0) | 0.95 | 76.5 (67.5–86.5) | 73.0 (65.0–78.0) | 0.10 | 78.0 (63.5–99.0) | 71.5 (68.0–73.0) | 0.47 |
DBP, Me (IQR), mm Hg | 75.0 (70–80) | 80 (70–80) | 0.86 | 77.5 (70–80) | 75 (70–80) | 0.86 | 75.5 (70–79) | 70 (70–75) | 0.32 |
SBP, Me (IQR), mm Hg | 120 (120–120) | 120 (120–120) | 0.20 | 120 (120–120) | 120 (120–120) | 0.10 | 120 (120–120) | 120 (120–120) | 0.56 |
HR, Me (IQR), b/min | 74.1 ± 2.7 | 73.9 ± 2.6 | 0.49 | 74.1 ± 2.8 | 73.1 ± 3.9 | 0.36 | 74.0 ± 2.5 | 74.0 ± 3.6 | >0.99 |
\(T,{}^{\overline{{X}}}\) ±SD, °С | 36.64 ± 0.15 | 36.63 ± 0.21* | 0.43 | 36.62 ± 0.10 | 36.60 ± 0.15 | 0.39 | 36.57 ± 0.08 | 36.58 ± 0.10 | 0.63 |
\({\rm{Acts}},{}^{\overline{X}}\) ±SD, times | 3.5 ± 1.9* | 2.8 ± 1.4* | 0.10 | 2.8 ± 1.1* | 2.0 ± 0.9* | 0.03 | 2.1 ± 0.9* | 1.3 ± 0.5* | 0.09 |
\({\rm{Dose}},{}^{\overline{X}}\) ±SD, tablets | 13.3 ± 1.9 | 12.2 ± 1.0 | — | 13.7 ± 2.2 | 12.0 | — | 12.0 | — | — |
