Table 1 Size, ζ potential, DTX content and drug encapsulation efficiency of DTX loaded NLs.

From: Optimization of Docetaxel Loading Conditions in Liposomes: proposing potential products for metastatic breast carcinoma chemotherapy

Formulation (Molar Ratio)

Z-Average (nm)

PDIa

ζ -potential (mV)

mg of DTX/ml

EEb (%)

Active loaded liposomes

F1a: HSPC/mPEG2000-DSPE/Chol (85/5/10)

109.8 ± 2.8

0.16 ± 0.00

−10.8 ± 0.2

1.7 ± 0.2

53.12 ± 8.8

F2a: HSPC/mPEG2000-DSPE/DPPG/Chol (85/5/5/10)

115.1 ± 2.8

0.17 ± 0.03

−12.4 ± 0.4

1.1 ± 0.1

34.3 ± 4.4

F3a: HSPC/mPEG2000-DSPE/DSPG/Chol (85/5/5/10)

116 ± 1.9

0.11 ± 0.00

−13.8 ± 0.0

2.15 ± 0.2

67.18 ± 6.6

Passive loaded liposomes

F1p: HSPC/mPEG2000-DSPE/Chol (85/5/10)

125.0

0.087

−10.3

0.64 ± 0.2

20 ± 6.2

F2p: HSPC/mPEG2000-DSPE/DPPG/Chol (85/5/5/10)

139.0

0.156

−10.9

0.57 ± 0.15

18 ± 4.7

F3p: HSPC/mPEG2000-DSPE/DSPG/Chol (85/5/5/10)

108.4

0.178

−13.7

0.83 ± 0.3

26 ± 0.94

  1. Each value depicts mean ± standard deviation (n = 3).
  2. aPolydispersity index, bEncapsulation Efficacy.
  3. Subscripts are abbreviations of active and passive loaded methods, respectively.
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