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Figure 1

From: 3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models

Figure 1

Therapeutic effect of 3′-sialyllactose (3′-SL) after elicitation in HDM-induced atopic dermatitis (AD) mouse model. Oral administration of 3′-SL and or Ketotifen as positive control done at 2-day intervals for 4 weeks after elicitation stage. (a) Variation in ear thickness during the course of HDM-induced AD. Atopic episodes during the experiment are shown as photographs. (d) Variation in ear thickness from 35 d before the experiment to the end of the experiment. Microphotographs of sections of the left ear 35 d after the onset of AD. The sections were stained with haematoxylin and eosin (H&E) (b) and Toluidine Blue (c). Original magnification was 100×. (e) Epidermal and (f) dermal thickness was quantified from H&E-stained microphotographs. (g) The number of infiltrating mast cells in the ear sections, as determined through Toluidine Blue staining. At least three randomly selected sites were analysed for each cell count experiment. Data are presented as mean ± SD values for each group (n = 6). #P < 0.05 between the HDM treated groups and the control group; *P < 0.05, **P < 0.01, ***P < 0.001 in comparison to HDM-treated group.

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