Figure 4 | Scientific Reports

Figure 4

From: 3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models

Figure 4

3′-Sialyllactose (3′-SL) protected house dust mite (HDM)-induced atopic dermatitis (AD) progress after onset of elicitation by downregulating pro-inflammatory cytokines in the AD-induced ear tissue of mice. Effect of 3′-SL on the expression of Th1 cytokines (a) IFN-gamma and (b) TNF-α; and Th2 cytokines (c) IL-4 (d) IL-5 and (e) IL-13; and other AD-related cytokines (f) IL-17 and (g) Tslp in HMD-inducecd ear tissue. The ears were excised on day 35, total RNA was isolated, and quantitative reverse transcriptase PCR analysis was performed. Data are presented as mean ± SD values for each group (n = 6). #P < 0.05 between the HDM-treated and control group; *P < 0.05, **P < 0.01, ***P < 0.001 in comparison to HDM-treated group.

Back to article page