Figure 6
From: Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity
Proposed mechanisms of neuroprotective effects of Tubastatin A against alpha-synuclein toxicity. The left side of the figure shows the potential mechanisms leading to dopaminergic neuron loss in the alpha-synuclein-injected substantia nigra (SN). On the right side of the figure, the effects of Tubastatin A are represented. Under these conditions, astrocytes are in a resting-like state, resulting in milder neuroinflammation, which may promote neuronal survival.
