Figure 6

Time-dependent sesquiterpene accumulation profiles from HDC cultures. (a–c) Volumetric titers of bisabolene, patchoulol and bisabolol, respectively. Quantities were measured by GC-FID directly from the dodecane overlay and normalized to the total culture volume (mg * L⁻¹). (d–f) Corresponding volumetric productivities calculated as the temporal yields (mg * L⁻¹ * d⁻¹) for growth phases 1 (0–48 h), 2 (48–96 h) 3 (97–120 h) and 4 (120–192 h), respectively. Statistical analysis was performed using the two-way ANOVA tool (with Tukey’s multi comparison test) of the GraphPad Prism software (version 8.2.1.). *Adjusted P < 0.05; **adjusted P < 0.01. (g–i) Specific product titers calculated as the quotient between volumetric titers and cell densities of the cultures (mg * L⁻¹ * OD₇₅₀⁻¹). The figures were prepared using Graphpad Prism 8.2.1. (https://www.graphpad.com/scientific-software/prism/).