Table 2 Responsiveness of astrocytes transfected with RFP-tagged TDP-43 pDNA constructs to noradrenaline- and isoprenaline-induced changes in intracellular cAMP and lactate levels.

Epac1-camps

RFP-TDP-43^wt

9 (100)

0 (0)

0 (0)

9

RFP-TDP-43^208–414

9 (100)

0 (0)

0 (0)

9

Laconic

RFP-TDP-43^wt

9 (42.8)

1 (4.8)

11 (52.4)

21

RFP-TDP-43^208–414

7 (70.0)

0 (0)

3 (30.0)

10

Laconic

RFP-TDP-43^wt

16 (64.0)

0 (0)

9 (36.0)

25

RFP-TDP-43^208–414

9 (60.0)

0 (0)

6 (40.0)

15