Figure 1
From: Two-Level Protein Methylation Prediction using structure model-based features
The methylation and demethylation processes for arginine and lysine. The histone on the top of the picture (PDB: 1KX5) includes four subunits: H2A, H2B, H3, and H4. There are many methylarginines and methyllysines on the H3 and H4 subunits (red letters). The methylation of arginine is shown on the left. Arginine methylation has three types: mono-methylation, symmetric di-methylation, and asymmetric di-methylation, which can be catalysed by Type I/II protein arginine methyltransferases (PRMTs). The methylation and demethylation of lysine are shown on the right panel, which also includes three types: mono-methylation, di-methylation, and tri-methylation. The lysine methylation can be catalysed by histone lysine methyltransferases (HKMTs or PRDMs), whereas the demethylation of lysine can be catalysed by lysine-specific histone demethylases (KDM1A and KDM2A).
