Figure 2 | Scientific Reports

Figure 2

From: Circulating RNA Transcriptome of Pregnant Women with TSH Just Above the Trimester-Specific Reference and its Correlation with the Hypertensive Phenotype

Figure 2

Interactive network analysis. (A) The protein-protein interaction (PPI) between 62 significant genes in gestational hypothyroidism with hypertensive phenotype hallmarks. The network was constructed using STRING by the required high confidence interaction score as 0.700. A total of 60 nodes were found, 115 number of edges with 3.83 average nodes degrees, 0.496 of clustering coefficient, 35 expected number of edges and a p-value <0.001. The yellow, purple, light blue and lilac lines represent the textmining, experimental data, databases and protein homology interactions, respectively. The blue nodes represent the immune system, red nodes the innate immune system and green nodes the cytokine signaling in the immune system, all with an FDR (False Discovery Rate) <0.001. (B) The interactive enrichment network gene was constructed by ToppCluster. The 62 common genes in gestational hypothyroidism and hypertensive phenotype hallmarks were shown in red and 131 fetal RNA is represented in light blue. 35.48% of 62 genes are related to fetal RNA.

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