Table 2 Functional annotation of set specific metabolite biomarkers.

L-LH

Cytosine

Pyrimidine base, product of CTP dephosphorylation. The CTP can transfer a phosphate to convert ADP to ATP.

5.71

8.37E-04

1.84

L-Gulonic gamma-lactone

Direct precursor of vitamin C.

2.83

4.71E-04

1.85

Phenoxybenzamine

Metabolite causes vasodilatation and increases cardiac output.

2.55

7.38E-03

1.68

Lavandulol

Pheromone.

2.06

5.57E-04

2.00

beta-Alanine

Neurotoxin, mitochondrial toxin, and metabotoxin when at a high level.

1.74

5.48E-05

2.09

Glutaric acid

Product during metabolism of some amino acids. Act as an acidogen and a metabotoxin when at high levels.

1.62

1.66E-03

1.89

H-HH

Pro-Tyr

Dipeptide.

5.14

9.23E-04

2.15

Pro-Asn

Dipeptide.

2.13

5.52E-04

2.15

Thr-Ala

Dipeptide.

2.10

4.08E-04

2.09

D-Glucose-6-phosphate

Metabolic hub.

3.20

1.37E-02

1.68

Ammelide

Hydrolysis product of melamine.

2.33

7.10E-05

2.17

S-Methyl-5’-thioadenosine

Metabolite influencing the regulation of gene expression, proliferation, differentiation, and apoptosis.

2.07

6.65E-03

1.83

4-Hydroxycinnamic acid

Important source of antioxidants.

2.05

2.54E-05

2.31

trans-2-Hydroxycinnamic acid

Important source of antioxidants.

2.02

5.25E-06

2.39

Theobromine

Vasodilator, diuretic and heart stimulator.

2.01

6.87E-03

1.70

N-Acetyl-D-glucosamine

Metabolite initiating a protective response to stress, modulating a cell’s capacity to grow and divide, and regulates gene transcription.

2.00

1.91E-03

1.90

Tiopronin

Reducing agent, neuroprotective agent.

1.99

5.42E-05

2.23

L-Phenylalanine

Metabolite could be converted to tyrosine, used in the biosynthesis of dopamine and norepinephrine neurotransmitters.

1.97

1.10E-02

1.66

Dimethylglycine

Byproduct of the metabolism of choline.

1.95

6.11E-03

1.78

Phe-Ala

Dipeptide.

1.92

1.74E-02

1.52

Ajmalicine

Monoterpenoid indole alkaloid, vasodilator agent.

1.87

4.52E-03

1.8