Figure 3
From: Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma
EBV infection down-regulates the expression of MAOA. (A) RT-qPCR analysis showed that the expression of MAOA was significantly reduced in an immortalised NPE cell line (NP460hTert) and four (CNE1, CNE2, HONE1, SUNE1) NPC cell lines stably infected with an Akata-derived recombinant EBV. Data are expressed as the relative expression between the cells infected with EBV and their respective controls (normalised to 1). (B) Western blot analysis showed that the protein levels of MAOA were reduced in NP460hTert and two NPC cell lines (CNE2 and HONE1) following EBV infection. (C) RT-qPCR and Western blotting analyses showed that both the mRNA and protein levels of MAOA were lower in HONE1 cells expressing specific EBV latent genes (EBNA1 or LMP2A) compared to the vector control cells. Full-length blots are presented in Supplementary Fig. S1. ***p < 0.001.
