Figure 2 | Scientific Reports

Figure 2

From: Role of Lectin-like Oxidized LDL Receptor-1 and Syncytiotrophoblast Extracellular Vesicles in the Vascular Reactivity of Mouse Uterine Arteries During Pregnancy

Figure 2

Effect of oxLDL on endothelium-dependent vasodilation in uterine arteries from WT and LOX-1tg mice. (a,c) Contribution of pre-incubation with (dashed lines; circles) or without (solid lines; squares) oxLDL (oxLDL-induced LOX-1 activation; 10 minutes before the start of the curve) to endothelium-dependent vasodilation responses to increasing doses of methylcholine (MCh) in uterine arteries from WT (a,b) and LOX-1tg mice (c,d) incubated overnight with (blue lines) or without STBEVs (black lines). (b,d) Summary graphs show the dose of to MCh necessary to establish 50% of total relaxation (pEC50) in uterine arteries from WT (b) and LOX-1tg mice (d) incubated overnight with (blue bars) or without STBEVs (white bars). Means with SEM; two-way ANOVA with Sidak’s multiple comparisons post-test; n.s.: not significant; ##p < 0.01, overall effect of treatment (control vs. oxLDL) in two-way ANOVA; *p < 0.05, control vs. oxLDL in multiple comparisons post-test. n = 8–9/group.

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