Figure 1

Confirmation of Neonatal Myocardial Infarction. Whole-mount confocal microscopy of fluorescent lectin-perfused neonatal mouse hearts at 1 hour after sham or myocardial infarction (MI) surgery on postnatal day 1 (P1). (a) For sham hearts (n = 4), fluorescent lectin signal is observed throughout the entire heart surface. The left anterior descending (LAD) coronary artery is labeled. (b) For MI hearts (n = 5), the LAD territory distal to the ligation suture (green arrow) is devoid of lectin signal (dotted blue trace), confirming successful LAD ligation.