Figure 2 | Scientific Reports

Figure 2

From: Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice

Figure 2

Infarct Size Analysis. Masson’s trichrome analysis of collagen scar formation at 4 weeks after sham or myocardial infarction (MI) surgery, performed in neonatal mice on postnatal day 1 (P1) or postnatal day 7 (P7). (a,b) Minimal intramural collagen scar was detected in the P1 sham (n = 4) and P1 MI hearts (n = 6). (c) No difference was observed among P1 sham and P1 MI hearts in the quantified percentage of collagen area relative to total left ventricular area. (d,e) Transmural collagen scar and adverse left ventricular remodeling were observed in the P7 MI hearts (n = 3) compared to sham controls (n = 3). (f) Percent collagen area relative to total left ventricular area was significantly greater for P7 MI hearts compared to P7 sham hearts. Data presented as mean ± standard error and compared using two-sample t-test. **Indicates p < 0.01.

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