Figure 3 | Scientific Reports

Figure 3

From: Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice

Figure 3

Assessment of Cardiomyocyte Proliferation. 5-ethynyl-2′-deoxyuridine (EdU) signal after sham or myocardial infarction (MI) surgery in neonatal mice on postnatal day 1. (a,b) Within the anterolateral left ventricular (LV) wall, compared to sham hearts, the MI hearts appeared to exhibit a greater density of EdU signal in the DAPI-stained nuclei of troponin+ cardiomyocytes, with (c) inset (dotted box) showing an EdU+/troponin+ cardiomyocyte (yellow arrow). (d) EdU+/troponin+ cells were significantly more prevalent per 20X region of interest (ROI) in MI hearts (n = 5) compared to sham hearts (n = 4) in all cardiac regions examined. Data presented as mean ± standard error and compared using two-sample t-test. **Indicates p < 0.01. ***Indicates p < 0.001.

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