Figure 4
From: Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice
Cancellous and cortical bone loss of the vertebrae after exposure to simulated spaceflight. Mice were fed either CD or DP diets, and either unloaded to simulate weightlessness (HU), irradiated with 2 Gy 137Cs (IR), or a combination of the two treatments (HU + IR). Vertebrae were analyzed by microCT for changes in bone microarchitectural parameters such as total (Tt) vertebral body bone volume fraction (Tt.BV/TV, Panel a) and total vertebral body trabecular thickness (Tt.Tb.Th, Panel b) as well as for changes in cortical bone parameters including cortical thickness (Ct.Th, Panel c) and cortical bone area (Ct.Ar, panel d). Data shown are mean + /− S.D. (n = 7–10/group). Different letters indicate p < 0.05,1-factor ANOVA with all pairs Tukey Kramer.
