Table 2 Organ absorbed dose per unit administered activity (mGy/MBq) for 211At-CXCR4 mAb using adult male human phantom and biodistribution data of 211At-CXCR4 mAb and 125I-CXCR4 mAb in human AML xenograft model in athymic mice.

From: Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using 211At-CXCR4 monoclonal antibody

Organ

Absorbed dose (mGy/MBq)

211At-CXCR4 mAb

125I-CXCR4 mAb

Brain

0.024

0.032

Eye

0.087

0.098

Salivary gland

0.331

0.153

Thyroid gland

0.985

0.298

Heart

0.773

0.912

Lung

0.399

0.488

Thymus

0.088

0.099

Liver

0.220

0.248

Gallbladder

0.087

0.099

Spleen

0.244

0.247

Pancreas

0.073

0.079

Esophagus

0.088

0.099

Stomach

0.088

0.099

Small intestine

0.088

0.099

Right hemicolon

0.087

0.099

Left hemicolon

0.087

0.099

Rectum

0.087

0.098

Adrenal gland

0.193

0.291

Kidney

0.287

0.402

Urinary bladder

0.087

0.098

Testis

0.492

0.185

Prostate gland

0.087

0.098

Bone

2.370

2.980

Red marrow

0.512

0.627

Total body

0.118

0.136

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