Figure 2

Hemodynamic responses before infarction. (a,c) Time-course curves of paired t-values of hemodynamic response in Monkeys 1 (a) and 2 (c) before infarction. The t-values for the paired t-test were calculated from the difference in hemodynamics during trials of left-hand and right-hand use in the session, using a food well with a diameter of 10 mm. The t-values of changes in oxygenated (ΔHbO) and deoxygenated (ΔHbR) hemoglobin in each channel (indicated by the numbers in each frame) are drawn with red and blue lines, respectively. The horizontal dotted lines in each frame indicate levels of p = 0.0001. The horizontal axis indicates time from the onset of the retrieval movement (vertical dashed line). The locations of the fNIRS optodes are indicated by gray circles with probe numbers (PR). (b,d) Color-mapping of t-values onto the anatomical MRIs for Monkeys 1 (b) and 2 (d). The t-values for ΔHbO around 5.0 s (for Monkey 1) and 5.5 s (for Monkey 2) after task onset are depicted. Amplitudes of t-values at most channels were maximal at this time. Arrowheads indicate the positions of the “hand knob” in M1 in the left hemisphere.